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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 38.79
Human Site: S416 Identified Species: 60.95
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 S416 F G S K C Q L S E K F F K A A
Chimpanzee Pan troglodytes XP_516332 1634 184611 S424 F G S K C Q L S E K F F K A A
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 S410 F G S K C Q L S E K F F K A A
Dog Lupus familis XP_534241 2041 231068 S834 F G S K C Q L S E K F F K A A
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 S404 F G S K C Q L S E K F F K A A
Rat Rattus norvegicus P41516 1526 173202 S393 F G S T C Q L S E K F I K A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 S719 F G S K C Q L S E K F F K A A
Chicken Gallus gallus O42131 1627 183228 S421 F G S K C Q L S E K F F K A A
Frog Xenopus laevis NP_001082502 1579 178601 S393 F G S K C T L S E K F I K G A
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 S415 F G S K C A L S E K F I R A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 K333 N K G G I N I K P F Q V R N H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 P406 V N C L I E N P T F D S Q T K
Sea Urchin Strong. purpuratus XP_783546 1448 163750 Q334 C L S E K G F Q Q V S F V N S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 K359 N V K A H N V K N H L W V F V
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 G314 S I A T T M G G T H V N Y I T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 100 N.A. 100 86.6 N.A. 100 100 80 80 N.A. 0 N.A. 0 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 86.6 N.A. 100 100 80 86.6 N.A. 13.3 N.A. 13.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 0 7 0 0 0 0 0 0 0 60 67 % A
% Cys: 7 0 7 0 67 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % D
% Glu: 0 0 0 7 0 7 0 0 67 0 0 0 0 0 0 % E
% Phe: 67 0 0 0 0 0 7 0 0 14 67 54 0 7 0 % F
% Gly: 0 67 7 7 0 7 7 7 0 0 0 0 0 7 0 % G
% His: 0 0 0 0 7 0 0 0 0 14 0 0 0 0 7 % H
% Ile: 0 7 0 0 14 0 7 0 0 0 0 20 0 7 0 % I
% Lys: 0 7 7 60 7 0 0 14 0 67 0 0 60 0 7 % K
% Leu: 0 7 0 7 0 0 67 0 0 0 7 0 0 0 0 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 14 7 0 0 0 14 7 0 7 0 0 7 0 14 0 % N
% Pro: 0 0 0 0 0 0 0 7 7 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 54 0 7 7 0 7 0 7 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 14 0 0 % R
% Ser: 7 0 74 0 0 0 0 67 0 0 7 7 0 0 7 % S
% Thr: 0 0 0 14 7 7 0 0 14 0 0 0 0 7 7 % T
% Val: 7 7 0 0 0 0 7 0 0 7 7 7 14 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _